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Vitiligo Patients must known

vitiligo patients must knownPeople all over the world not matter male or female, belong to witch nationality can have vitiligo, the morbidity is different in different areas, races and color of skin, generally speaking, the people with dark complexion have higher morbidity, such as the morbidity is America is less than 1% and reach to 4%, in our country is between 0.1%-2%. The occurrence of vitiligo have no obvious relationship with gender, different age groups all can have vitiligo, but the teenager occupy the most. The age of onset under 20 years old occupy the half of the number of infected. Each of the whole body part can be infected, the skin lesion is local pigment loss patches, always is milky white also can be shallow pink, the surface is smooth and without rash. The vitiligo edge is clear, the pigment is the edge increased compare with the normal skin, the fair in the vitiligo can be white and also can be normal. The lesion often happens in the exposure to the sunlight and friction damage part such as face, upper leg, neck, forearm stretch side, back of the palm, waist, abdomen, sacrococcygeal region, armpit, elbow knee, private parts and so on. The lesion part always distribute symmetrically. Vitiligo often distribute in the shape of strip along the spinal segments, this kind of vitiligo belong to unilateral onset. Except for skin lesion, the lips, labia, glans penis and wrapping the medium mucosa always involved. The vitiligo can generalized to the whole body but the melanin pigment in the retina, choroid, pia mater will not involved. Sometimes the vitiligo area have regenerate pigments after exposure to the sunlight; the center or edge of the vitiligo have some melanin regenerate while in the winter in the center or edge of the vitiligo have some pigment decreased. About 20% vitiligo patients very sensitive to ultraviolet, their vitiligo spreading very fast after exposure to the sunlight. The mechanical stimulate such as needling, scratching, the pressure on skin (tights, Hernio joe and so on) and other local stimulation, such as fire burn, infection, sunburn, frostbite, radioactive rays and so on can make the vitiligo patients have white patches on their normal skin, or extend the original vitiligo even regenerated to the whole body have isomorphic reaction. The number of vitiligo is uncertain, but few can change or spontaneous disappeared, but most vitiligo cases shown that vitiligo gradually increased or extend, the adjacent vitiligo integrated into irregular large scale patches even generalized into whole body.

This disease in most situations have no self-conscious symptoms, a few vitiligo patients have local itch sensation before they the onset of vitiligo. Vitiligo always accompany with other autoimmune diseases such as diabetes, thyroid disease, adrenal insufficiency, pernicious anemia, rheumatic arthritis, scleroderma, atopic dermatitis, alopecia areata and so on. According to the morphology, sites, scope and treat effect of vitiligo, clinically divided into four types:

① Localized type, vitiligo single shot or cluster in certain sites;

② Sporadic type, white patches with different sizes most symmetrically scattered;

③ Generalized type always developed from the above two types, the disease area is more than half of the surface skin;

④ Segmental type, white patches distribute along the nerve segment or dermatomere. This disease can divided into complete and incomplete these two types of vitiligo according to the pigment loss condition in disease lesions. The former part response to DOPA is negative, the melanophore disappeared, the treatment response is poor. The later one response to the DOPA is positive, the number of melanophore decreased, the cure rate is higher than former one.

【Examine】

1.Electrolyte and inorganic element tests.

2. Routine urine test.

3. Thyroid function test.

4. Detection of metabolites.

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