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What Is Isomorphic Reaction Of Vitiligo

isomorphic reaction of vitiligoWhat is isomorphic reaction of vitiligo? What is isomorphic reaction? In the following part, I’d like to make a brief introduction about the isomorphic reaction of vitiligo for your reference.

Isomorphic reaction is the normal skin damaged induce the existed skin lesion of certain skin disease. The vitiligo isomorphic reaction is a phenomenon that the local skin get vitiligo or original vitiligo enlarged after the skin inflammation or suffer from external injuries. Isomorphic reaction is the common clinical presentation, it also one of the inducements of vitiligo.

Koebner Phenomenon mostly occur in the progressive stage of vitiligo. If the vitiligo in the stable stage have vitiligo, it indicates their vitiligo might will developed. Most of the koebner phenomenon occur in the injuries, skin and soft tissue infectious areas. Generally it occurred in the skin damaged areas after about one month. But the koebner phenomenon happen should have a pretext that is the basal cell of the epidermis or dermis damaged. If only damaged the cuticle areas, generally will not induce isomorphic reaction.

The occur of isomorphic reaction might related with the melanocyte in the basal layer damaged. In the wound healing process, some released cell factors, free radicals, cytotoxic substances induced by the bacteria and lymphocytic infiltration and etc. These factors can make the abnormal melanocyte more easier to be damaged. The vitiligo isomorphic reaction belongs to the autoimmunity phenomenon.

The research data shows that the external use medicine irritations, all kinds of skin disease inflammations, surgery, friction all can worsen vitiligo. The vitiligo patients should avoid these factors.

The critical factor to prevent isomorphic reaction is to avoid skin damage. The precondition of isomorphic reaction of vitiligo is external injuries especially in the progressive stage of vitiligo.

After the isomorphic reaction appeared, the patients need to avoid using medicines with strong irritation, auto epidermal skin grafting surgery and etc. If you have any question about vitiligo, welcome mail to


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