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Does Vitiligo Related With Endocrine

does vitiligo related with endocrineVitiligo is a skin disease caused by many factors. In the following part, I’d like to talk about does vitiligo related with the endocrine. In the following part, I'd like to make a brief introduction about this.

Endocrine system is a information delivery system in the body combined by the endocrine gland and the endocrine cells in some organs, it closely related with the nerves and immune system, they coordinate with each other and together to adjust the physiological activity in the body and maintain the internal environment relatively stable. The high performance living matter secrete by the endocrine gland or endocrine cells---hormone, this substance play a role via the delivery of tissue fluid and blood. The research indicates that he melanocyte stimulating hormone, skin stimulating hormone, sexual hormone all can promote the melanin synthesis and metabolism. The glucocorticoid, adrenaline, noradrenaline, thyroxine and melatonin can inhibit the melanin pigment metabolism and synthesis, all these indicates the vitiligo closely related with the endocrine.

1. Melanocyte stimulating hormone: there have research indicates the melanocyte stimulating hormone might secrete by the secretory cells of the pituitary gland, the melanocyte stimulating hormone divided into α and β these two kinds. Α melanocyte stimulating hormone have no effects or have very less effects to the melanocyte. The β melanocyte estrogen closely related with the pigment proliferative diseases.

2. Corticosteroid: corticosteroid secrete by the adrenaline, the artificial synthesized cortical hormone includes prednisone, dexamethasone and etc. It’s effect to the melanin metabolism mainly related with the melanocyte stimulating hormone. In normal condition, the level of melanocyte stimulating hormone and glucocorticoid is relatively balanced, once it disorder, it will influence the skin color.

3. Skin stimulating hormone: this hormone secrete by the anterior pituitary, according to the clinical observation, many patients after use the skin stimulating hormone, the color of their original pigmented nevus deepen, locally apply this medicine, their skin color become deeper, all these related with the skin stimulating hormone contains melanocyte stimulating hormone.

4. Adrenaline and noradrenaline: according to the experiments in the animals, it indicates that the trace adrenaline and noradrenaline can inhibit the effect of melanocyte stimulating hormone to the melanocyte of isolated frog skin.

5. Thyroxine: it secrete by the thyroid gland, there are four iodine glandular acid and three iodine glandular acid these two kinds, they are all the iodide of the tyrosine.

6. Sexual hormone: it includes estrogen, progesterone. These hormones can activate by the tyrosinase inhibited by the mercapto.

All I mentioned above proved that the vitiligo closely related with the endocrine. If you have any question about this, welcome mail to


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