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The Pathogenesis of Vitiligo

the pathogenesis of vitiligoVitiligo is a common stubborn chronic skin disease, the symptoms of vitiligo seriously damaged the appearance of the patients even will make them suffer from the discrimination of others and seriously influenced their social contact and cause huge mental pressure to them. But there are many people still dim about the pathogenesis of vitiligo, in this article, I’d like to briefly introduce the pathogenesis of vitiligo for your reference.

1. Lack of trace elements, immune system disorder.

Trace elements such as zinc, copper, iodine and so on can participate in the metabolism of the body, if the lack of some trace elements necessary in the synthesis of melanin pigment will induce the vitiligo. Because trace elements can avoid the toxic substances damage the pigment cells, if the lack or unbalance of some trace elements will cause the obstruction in the pigment cell synthesis process.

Anti melanocyte antibody induced by the endocrine function disorder and make the immune system disorder, it can not recognize autologous pigment cells, make the antigens have immune reaction and cause the autologous pigment cells damaged and finally formed localized vitiligo.

2. Genetic factor.

According to the research, we found vitiligo exist genetic factor and even will atavism. So even both of the parents have no vitiligo, if there are family member in either parent family have vitiligo history, the patient’s have great chance caused by genetic factor.

3. External injuries and external irritations.

Some burns, frostbites, surgeries, external injuries and so on all can damage the melanocytes, cause the part of skin whiten and even might cause the vitiligo far from the injuries. If the vitiligo patients injured, they must handle it properly, because the stress changes, immune system disorder, nerve chemical factor and so on can cause sporadic or generalized vitiligo.

Some external skin irritations such as pressing, friction, scratching and so on also can cause vitiligo. Such as some patients with vitiligo in their nose bridges of the two side of nose, ears, it caused by the damage of melanocytes, if let it go will cause the immune function disorder and cause vitiligo at other sites.


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