In clinic, 308 excimer laser treatment for vitiligo is very useful and effective for vitiligo treatment. And in many countries, 308 laser treatment is a common therapy for vitiligo. 308nm excimer laser is one kind of excimer laser, meaning Xecl excimer laser. It belongs to continuous pulsed gas laser. The wavelength is during the range of UVB, and the pulse width is usually 10-30 ns.
Nowadays, the causes and pathogenesis of vitiligo are still not clear yet. There are many hypothesis to explain various clinical manifestation of different vitiligo patients. Why 308nm excimer laser therapy can treat vitiligo? Its therapy mechanism may be related to T lymphocyte apoptosis. Bian2chi and other people have researched by using immunohistochemical method that 308nm excimer laser can clean up the infiltrative T lymphocyte at lesion positions. Novak and others have researched that 308nm excimer laser can promote the activated T lymphocyte at vitiligo lesion positions apoptosis. The treatment effect is quite obvious, even more obvious than NB-UVB's ability to cause apoptosis.
After 308 laser irradiation, it can lead to T lymphocyte apoptosis, thus making the vitiligo lesions disappear not only from naked eye levels, but also making the structures recover to be normal on micro level. vitiligo is characteristic by selective melanophore, it may relate to patients' autoimmune response. Narrow band ultraviolet( NB-UVB) may have immunomodulatory effects to make human cells and body fluid generate immunity, which can help to stabilize depigmentation progress. Besides, NB-UVB has been widely identified as similar as PUVA(psoralen photochemical therapy), which can stimulate remained melanophore to gather around peripheral hair follicle outer root sheath. Melanophore can go on mitosis, the generation and movement of melanin, always be induced by various cytokines and inflammatory mediator, including interleukin, tumor necrosis factor α, leukotriene C4. Recent researches indicate that after UVB irradiation, various cytokines and inflammatory mediator will increase, which indicates that this is on mechanism of UVB inducing the restore of melanin.Top
1. Stimulate the proliferation of melanophore, promote melanin growth.
2. Induce T lymphocyte apoptosis.
3. Promote the generation of vitamin D3 .
4. Activate false catalase.Top
Compared with traditional treatment, the biggest advantage of 308 laser treatment is the rapid and everlasting effect. Besides, it is very safe.
For vitiligo patients, the traditional treatment contains oral medicines and external medicines, but they can not ensure effect. UV phototherapy usually needs about hundreds times treatment. And the effect is limited. But laser just needs 2-4 courses to reach above 75% complete recovery.Top
1. The early vitiligo patients
2. Segmental type vitiligo, usual type vitiligo, hair follicle type vitiligo, local type vitiligo and etc.
3. Patients who are troubled by vitiligo for long time.
4. Patients whose vitiligo repeated attack.
5. vitiligo children patients.Top
1. The treatment effect is better for vitiligo on face, neck, trunk, arms and legs.
2. Patients not beyond 18 years old, and week vitiligo patients.
3. Pregnant women.
4.For development period vitiligo patients, Xtrac excimer laser treatment system has better effect.Top
When experts are using excimer laser to treat vitiligo, there are individual differences, which are related to the following factors: skin color(skin type), lesion period,(short disease time will have fast recovery), lesion positions(head, face, trunk have best treatment effect, then arms and legs, and last finger dorsum,the centre of the palm, vola treatment is difficult). Some patients are doubting why other patients' laser treatment effect is very good, but their laser treatment has no effect. And they also ask why some positions recover fast, but other positions recover very slowly. The following is some explanation.
The ordinary type vitiligo, the direct reason is the death of melanophore killed by T lymphocyte. When T lymphocyte is going on immune killing, it needs to identify the aim's identity, which means T lymphocyte will identify and kill melanophore specially when people get vitiligo. In human hair follicle, the melanophore in original state will not express the feature symbol of melanophore. Therefore, they can escape from the damage of T lymphocyte. The recovery of vitiligo needs excimer laser treatment to stimulate these remained and original melanophore to grow into mature melanophore with function to help skin recover. This is the reason why there are pigment islands around sweat pores when vitiligo gets recovery. And then the island will enlarge and get recovery finally. The reason why different positions have different treatment effect may be related to hair follicle's density of distribution, type, blood supplement and etc. But the centre of the palm and vola don't have hair follicle, therefore, the treatment is the most difficult.
Beijing CASU vitiligo hospital UMD multidimensional treatment system experts indicate that for different positions and treatment period, the treatment dose is also different. Although 308 excimer laser has many advantages, not all vitiligo patients can see the effect. vitiligo experts need to make specific treatment plan for you according to your condition. If the dose is small, it can not play treatment effect. If the dose is too much, it will damage skin. Different doctors will make different treatment plan, therefore, remind you go to specialized vitiligo hospital to do treatments.Top
In certain curative dose, excimer laser is a comparatively safe therapy for skin disease treatment. It has no risk to lead to cancer. The laser's square focus spot can avoid laser irradiating normal tissues and then furthest decrease the damage to normal skin.
Many vitiligo patients are also worried about whether laser treatment has side effect their body. During treatment, patients may feel slight burning heat sensation just on irradiation parts. Some patients also feel a little pain at lesion positions several hours later after the treatment. For some psoriasis patients, their skin may get some erythema, or have hyperpigmentation several hours later after treatment(restorable). For vitiligo patients, there are almost no side effects. Sometimes, the enhanced energy will lead to slight bubble.
Besides, some vitiligo patients want to know if excimer laser can lead to skin cancer. In traditional phototherapy to treat vitiligo, especially UVA(PUVA) or UVB, there are some reports saying that they lead to skin cancer. 308 excimer laser has no reports like that. 308 laser treatment is a safe vitiligo treatment to all age groups from babies to old people.Top
Someone ask about the cost of 308 excimer laser, in different hospitals, the charging standard has great differences. Generally speaking, it is calculated according to light spots. Each light spot is about 6-8 dollars per time. If your vitiligo area, hundreds of light spots needs quite much money. Therefore, pure laser therapy is a treatment costing lots of money. Therefore, you need doctors to make specific treatment plans for you according to your vitiligo condition.Top
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